Regulation of lung immune-epithelial networks sensing environmental change

肺免疫上皮网络感知环境变化的调节

• 批准号: DP230101156
• 负责人: Prof Gabrielle Belz
• 金额: $ 49.79万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101156
• 关键词: Regulation; lung; immune; epithelial; networks

This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.

这项研究旨在揭示肺上皮细胞如何与免疫细胞结合，并确定它们的细胞和分子布线，以确保肺组织的稳态维持和必要的修复过程。肺上皮免疫网络的维持对于维持正常的肺组织结构和功能以及诱导免疫应答以保护免受微生物挑战或吸入的潜在有毒物质是必不可少的。了解上皮免疫细胞介导的传感/修复的分子程序对于了解组织修复过程如何在肺中驱动至关重要，肺是呼吸和生命的关键器官。