Investigation of the physiological consequences of Cu/Zn SOD deficiency in drosophila melanogaster

果蝇 Cu/Zn SOD 缺乏的生理后果研究

• 批准号: 298518-2008
• 负责人: Parkes, Tony
• 金额: $ 1.46万
• 依托单位: Nipissing University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=427619
• 关键词: Investigation; physiological; consequences; Cu; Zn

The free radical theory of aging suggests that aging results from an accumulation of damage to cellular components, resulting in cell death, tissue and organ failure, and eventually the death of the organism. The source of this damage is believed to be reactive oxygen species (ROS), produced as toxic byproducts of normal metabolism. ROS are implicated in a variety of age-related disorders including diabetes, cancer, atherosclerosis, and neurodegenerative disease. ROS are highly reactive molecules capable of damaging cellular components including DNA, proteins, and membranes. As well as directly damaging cells, ROS play critical physiological roles by modulating many of the cell signaling pathways which control gene expression. Unfortunately, most of our insights into the biological roles of ROS have been derived from studies in cell culture systems, and their significance to functioning tissue in an intact whole organism remains uncertain.

衰老的自由基理论表明，衰老是细胞成分损伤累积的结果，导致细胞死亡，组织和器官衰竭，最终导致生物体死亡。 这种损伤的来源被认为是活性氧（ROS），作为正常代谢的有毒副产物产生。ROS与多种年龄相关疾病有关，包括糖尿病、癌症、动脉粥样硬化和神经退行性疾病。ROS是能够破坏细胞组分（包括DNA、蛋白质和膜）的高反应性分子。除了直接破坏细胞外，ROS还通过调节许多控制基因表达的细胞信号通路发挥重要的生理作用。不幸的是，我们对ROS生物学作用的大部分见解都来自细胞培养系统的研究，它们对完整生物体中功能组织的重要性仍然不确定。