Advancing Couple and Family Alcohol Treatment through Patient-Oriented Research and Mentorship

摘要 酒精滥用对亲密伴侣暴力（IPV）有显着的急剧影响，这是一个持续的公众 健康危机影响了大约三分之一的美国人口。创伤后应激障碍（PTSD）是 高度流行，对酒精滥用有明显的因果关系，并且是IPV的一个可靠的独立预测因子。 然而，很少有研究探讨创伤后应激障碍和酗酒对IPV的综合影响。这个问题 是至关重要的解决，因为有效的预防和治疗方法，酒精相关的IPV是稀缺的。 将这两个孤立的文学领域结合起来，可以帮助我们了解小说的发展， 使夫妇产生更强大和更可持续的结果的模式。弗拉纳根医生是最理想的人选 来推进这一领域的临床科学。根据拟议的中期职业发展奖，她将 通过提高她的口服酒精技能，加速她蓬勃发展的以病人为导向的酒精研究计划 管理，2）强化门诊评估，和3）心理生理学。她将实现这些目标 通过专家咨询、教学培训和实施拟议的研究项目。她的团队 将研究酒精滥用和创伤后应激障碍对酒精相关IPV的综合影响。 无论是在受控的实验室环境中还是在自然环境中。这项研究旨在补充 学员的独立研究兴趣，还将比较不同环境的结果，并探索心率 变异性作为假设关系的生理机制。宝贵的保护时间 K24提供的资源将使弗拉纳根博士能够实现她的主要目标， 在这个关键的职业生涯中期阶段，她将参与一个教学计划， 专家辅导，以扩大她在多样性，公平和包容性方面的投资，指导，领导， 科学实现这些协同目标将加速科学的夫妇和家庭酒精的研究 并为创新的新型二元治疗奠定基础。这个奖项也将确保弗拉纳根博士 以支持下一代热情的新调查人员，并确保这一重要的，但 酒精领域的代表性不足。

ABSTRACT Alcohol misuse has a salient precipitous effect on intimate partner violence (IPV), which is a persistent public health crisis affecting approximately one-third of the U.S. population. Posttraumatic stress disorder (PTSD) is highly prevalent, has a clear causal effect on alcohol misuse, and it is a robust independent predictor of IPV. However, few studies have examined the combined effects of PTSD and alcohol misuse on IPV. This question is critical to address because effective prevention and treatment approaches for alcohol-related IPV are scant. Integrating these two siloed areas of the literature can help inform the development of novel, trauma-informed modalities for couples to produce stronger and more sustainable outcomes. Dr. Flanagan is the ideal candidate to advance the clinical science in this area. Under the proposed mid-career development award, she will accelerate her thriving patient-oriented alcohol research program by enhancing her skills with 1) oral alcohol administration, 2) intensive ambulatory assessment, and 3) psychophysiology. She will achieve these goals through expert consultation, didactic training, and implementation of the proposed research project. Her team will examine the combined effects of alcohol misuse and PTSD on alcohol-related IPV among couples (N=70) in both a controlled laboratory setting and in naturalistic settings. The study, which was designed to complement mentees’ independent research interests, will also compare outcomes across settings and explore heart rate variability as a physiological mechanism underlying the hypothesized relations. The invaluable protected time and resources provided by this K24 will enable Dr. Flanagan to achieve her primary goal of expanding her mentoring availability and skillset at this pivotal mid-career stage. She will engage a program of didactics and expert coaching to amplify her investment in diversity, equity, and inclusion in mentoring, leadership, and science. Achieving these synergistic objectives will accelerate the science of couple and family alcohol research and set the stage for innovative new dyadic treatments. This award will also ensure that Dr. Flanagan is equipped to support the next generation of enthusiastic new investigators and to ensure the longevity of this vital yet underrepresented area of the alcohol field.