Transient tissue ‘priming’ via FAK inhibition to impair pancreatic cancer progression and improve sensitivity to gemcitabine/Abraxane

癌症药物的成功取决于许多因素，包括肿瘤组织的性质。随着肿瘤的生长，它会改变周围的组织，这会影响对治疗的反应。将经典生物学与工程学相结合，以生成模拟肿瘤的3D模型，沿着尖端成像技术和小鼠模型，我们将靶向FAK控制的癌细胞通路，这些通路可以感知组织变化，以及已经批准的癌症药物，以改善患者的预后。

The success of cancer drugs is dependent on many factors including the properties of the tumour tissue. As a tumour grows it changes the tissue around it, and this affects response to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology and mouse models, we will target FAK-controlled cancer cell pathways that sense tissue changes, together with already approved cancer drugs to improve patient outcome.