Real-time optical window imaging of AKT-FRET biosensor mice to maximise PI3K/AKT drug targeting within the hypoxic microenvironment of pancreatic cancer.

实体肿瘤组织中药物反应的低效往往是癌症治疗临床有效性的一个限制因素。使用尖端成像技术和模拟这种疾病的3D模型，我们已经在低氧水平的肿瘤的不同区域绘制了药物反应差的区域，即所谓的低氧。在这里，我们将特别针对在这些领域限制有效药物靶向的因素，以改善AKT抑制剂在胰腺癌中令人鼓舞的抗癌作用。

Inefficient drug response in solid tumour tissue is often a limiting factor in the clinical effectiveness of cancer therapies. Using cutting-edge imaging technology and 3D models that mimic the disease, we have mapped areas of poor drug response within distinct regions of tumours with low oxygen levels known as hypoxia. Here, we will specifically target factors limiting efficient drug targeting in these areas to improve the encouraging anti-cancer profile of AKT inhibitors in pancreatic cancer.