Cellular and molecular interactions determining whether antigen signals the activation or inactivation of CD4 T cells

细胞和分子相互作用决定抗原是否发出 CD4 T 细胞激活或失活信号

• 批准号: 327335-2008
• 负责人: Bretscher, Peter
• 金额: $ 3.64万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=428788
• 关键词: Cellular; molecular; interactions; determining; whether

The immune system exists in all vertebrates and provides a sophisticated defense against invaders. It has the remarkable property of being able to fight these invaders in a very specific way, such that the immune response to one virus, say, is only effective against this virus and not another virus. This is the property of specificity. The interaction of the recognition molecules of the immune system and the invader is often likened to the interaction of a key with its lock. Secondly, the immune system appears to be able to fight every invader it encounters. This property is called universality. Specificity and universality can be likened to a key shop, that has keys on hand able to open every lock in the world, even those not yet invented! Molecules able to be recognized by these specific molecules are called antigens.

免疫系统存在于所有脊椎动物中，并提供对入侵者的复杂防御。它具有能够以非常特定的方式对抗这些入侵者的显着特性，例如，对一种病毒的免疫反应只对这种病毒有效，而不是另一种病毒。这就是特异性的性质。免疫系统的识别分子和入侵者的相互作用通常被比作钥匙与锁的相互作用。其次，免疫系统似乎能够对抗它遇到的每一个入侵者。这种性质称为普遍性。具体性和普遍性可以比喻为一个钥匙店，那里的钥匙可以打开世界上的每一把锁，即使是那些还没有发明的锁！能够被这些特异性分子识别的分子称为抗原。