Characterization of drug disposition in skeletal tissues - a forensic context

点击翻译按钮获取中文摘要

In many notorious death investigations, the remains under investigation have decomposed to the point of partial or complete skeletonization. In such cases, elucidating the role of drugs or poisons in the events leading up to or associated with the death is extremely challenging. Conventional toxicological analyses, usually done on fluids such as blood or urine, or tissues such as liver, are often not possible. In these cases, analysis of skeletal tissues (mineralized bone and/or bone marrow) may be the only remaining option. This research program will address this problem through characterization of drug concentrations in skeletal tissues in a forensic context.