The interactions of drugs with biological and liposomal membranes

药物与生物膜和脂质体膜的相互作用

• 批准号: 341920-2007
• 负责人: Heerklotz, Heiko
• 金额: $ 2.08万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=429944
• 关键词: interactions; drugs; biological; liposomal; membranes

The proposed work aims at establishing quantitative biophysical rules describing the interaction of drugs and other small molecules with biological and liposomal membranes. These are of fundamental interest since virtually all drugs have to interact with membranes; they may bind to membrane receptors, act by changing membrane properties, or need to cross membranes to reach their target. Furthermore, artificial membranes (liposomes) are loaded with drugs for targeted drug delivery and optimized release.

拟议的工作旨在建立定量的生物物理规则，描述药物和其他小分子与生物和脂质体膜的相互作用。这些都是基本的兴趣，因为几乎所有的药物都必须与膜相互作用;它们可能与膜受体结合，通过改变膜特性起作用，或者需要穿过膜才能到达靶点。此外，人工膜（脂质体）装载有药物，用于靶向药物递送和优化释放。