How do TRIM21 and TRIM5α execute dual antiviral effector and signalling functions?

TRIM21 和 TRIM5α 如何执行双重抗病毒效应和信号传导功能？

• 批准号: nhmrc : GNT1110116
• 负责人: Dr Claire Dickson
• 金额: $ 34.47万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trim21-trim5-execute-signalling-functions/1346711
• 关键词: How; do; TRIM21; TRIM5; execute

We encounter millions of potential pathogens each day that must be detected and disarmed by the immune system. Recently, two antiviral proteins, present inside cells, were shown to both detect viruses, alerting neighbouring cells to the infection, and target the viruses for destruction. These two functions provide important protection against viral infection and this research aims to understand at a molecular level, how these dual antiviral functions are coordinated.

我们每天都会遇到数百万种潜在的病原体，这些病原体必须被免疫系统检测到并解除武装。最近，两种存在于细胞内的抗病毒蛋白被证明可以检测病毒，提醒邻近细胞感染，并靶向病毒进行破坏。这两种功能提供了对抗病毒感染的重要保护，这项研究旨在从分子水平上了解这两种抗病毒功能是如何协调的。