Is the tumour suppressor activity of p53 independent of its transcriptional role?

p53 的肿瘤抑制活性与其转录作用无关吗？

• 批准号: nhmrc : 567086
• 负责人: Dr Katherine Baran
• 金额: $ 10.86万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tumour-suppressor-activity-transcriptional-role/116045
• 关键词: tumour; suppressor; activity; p53; independent

To become cancerous, a cell must avoid death. As such, cancer cells often contain defects in cell death pathways which render them resistant to pro-death stimuli, including many chemotherapeutic drugs. To design new and better cancer therapies, it is essential that we understand the critical molecular processes that control cell death. This will allow the development of more effective ways to either reset, or bypass, defects in cell death pathways which have contributed to cancer formation.

要成为癌细胞，细胞必须避免死亡。因此，癌细胞通常在细胞死亡途径中含有缺陷，这使得它们对促死亡刺激（包括许多化疗药物）具有抗性。为了设计新的更好的癌症疗法，我们必须了解控制细胞死亡的关键分子过程。这将允许开发更有效的方法来重置或绕过导致癌症形成的细胞死亡途径中的缺陷。