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Advanced bioanalytical mass spectrometry techniques for investigating the mechanism of protein binding by reactive metabolites

Advanced bioanalytical mass spectrometry techniques for investigating the mechanism of protein binding by reactive metabolites
先进的生物分析质谱技术用于研究反应性代谢物与蛋白质结合的机制
批准号：
355933-2008
负责人：
Sleno, Lekha
金额：
$2.49万
依托单位：
Université du Québec à Montréal
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-01-01 至 2010-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=431848
关键词：
Advancedbioanalyticalmassspectrometrytechniques

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英文摘要
The main role of drug metabolism is to detoxify the body from xenobiotics, rendering them more polar and thus more easily cleared. Some drugs, however, are bioactivated into reactive metabolites having the potential to covalently bind to proteins. This binding is considered to be an important cause of idiosyncratic (rare and unpredictable) drug reactions (IDRs) and, as a result, the formation of these metabolites represents a significant liability for new pharmaceutical compounds. The way in which certain drugs exhibit their toxicity can be highly variable and the exact mechanisms are still quite unclear. Designing new methods to study these
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Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2022
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2021
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2020
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2019
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
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