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Advanced bioanalytical mass spectrometry methods for investigating the mechanism of protein binding by reactive metabolites

Advanced bioanalytical mass spectrometry methods for investigating the mechanism of protein binding by reactive metabolites
用于研究反应性代谢物的蛋白质结合机制的先进生物分析质谱方法
批准号：
355933-2011
负责人：
Sleno, Lekha
金额：
$2.55万
依托单位：
Université du Québec à Montréal
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-01-01 至 2014-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527962
关键词：
Advancedbioanalyticalmassspectrometrymethods

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英文摘要
The main role of drug metabolism is to detoxify the body from xenobiotics, rendering them more polar and thus more easily cleared. Some drugs, however, are bioactivated into reactive metabolites with the potential to covalently bind to proteins. These reactive metabolites can bind to proteins in vivo and cause administration of these drugs to be potentially very dangerous. The goal of our research program is to design new innovative methods to study these toxic interactions. Our focus is to devise a strategy to further understand binding of reactive metabolites to proteins using a combination of modern mass spectrometry tools for studying both small molecules and proteins.
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Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2022
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2021
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2020
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
Advanced bioanalytical mass spectrometry methods for investigating protein covalent binding by reactive metabolites
  • 批准号：
    RGPIN-2016-06034
  • 项目类别：
    Discovery Grants Program - Individual
  • 资助金额：
    $2.62万
  • 财政年份：
    2019
  • 负责人：
    Sleno, Lekha
  • 依托单位：
    Université du Québec à Montréal
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