The role of lipogenesis in the metabolic regulation of exocytosis

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How insulin-secreting beta-cells sense glucose is incompletely understood. Our group has developed a modern set of tools that provide a unique opportunity to gain major new insights in this area. The goals of our laboratory are to apply these newly developed tools to study stimulus/secretion coupling mechanisms in insulin-secreting beta-cells. We will investigate the role of lipid production in the control of insulin release from insulin secreting cells. These studies will provide new insights into relevant pathways involved in sensing sugar levels in the blood by insulin-secreting beta-cells and will have important implication towards the understanding of the metabolic regulation of insulin secretion.