The role of lipogenesis in the metabolic regulation of exocytosis

脂肪生成在胞吐作用代谢调节中的作用

• 批准号: 371723-2009
• 负责人: Joseph, Jamie
• 金额: $ 2.19万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=483708
• 关键词: role; lipogenesis; metabolic; regulation; exocytosis

How insulin-secreting beta-cells sense glucose is incompletely understood. Our group has developed a modern set of tools that provide a unique opportunity to gain major new insights in this area. The goals of our laboratory are to apply these newly developed tools to study stimulus/secretion coupling mechanisms in insulin-secreting beta-cells. We will investigate the role of lipid production in the control of insulin release from insulin secreting cells. These studies will provide new insights into relevant pathways involved in sensing sugar levels in the blood by insulin-secreting beta-cells and will have important implication towards the understanding of the metabolic regulation of insulin secretion.

分泌胰岛素的β细胞如何感知葡萄糖尚不完全清楚。我们的团队开发了一套现代化的工具，为获得该领域的重大新见解提供了独特的机会。我们实验室的目标是应用这些新开发的工具来研究胰岛素分泌β细胞的刺激/分泌耦合机制。我们将研究脂质产生在控制胰岛素分泌细胞的胰岛素释放中的作用。这些研究将为胰岛素分泌β细胞感知血液中糖水平的相关途径提供新的见解，并对理解胰岛素分泌的代谢调节具有重要意义。