Understanding allosteric modulation and biased signalling at Family B GPCRs

了解 B 族 GPCR 的变构调节和偏向信号传导

• 批准号: nhmrc : GNT1089966
• 负责人: Dr Denise Wootten
• 金额: $ 41.18万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-allosteric-modulation-b-gpcrs/1345780
• 关键词: Understanding; allosteric; modulation; biased; signalling

Family B GPCRs are therapeutic targets for drugs treating osteoporosis, hypercalcaemia, Paget’s disease, type II diabetes and are being actively pursued for other diseases that represent major global health burdens. Despite huge financial input, there are no orally available drugs that act on these receptors. This speaks to a lack of mechanistic understanding of how they work. My research focuses on addressing this question and how to exploit these receptors to design and identify better drugs.

家族B GPCR是治疗骨质疏松症、高钙血症、佩吉特病、II型糖尿病的药物的治疗靶点，并且正在积极寻求用于代表主要全球健康负担的其他疾病。尽管有巨大的财政投入，但没有口服药物作用于这些受体。这说明缺乏对它们如何工作的机械理解。我的研究重点是解决这个问题，以及如何利用这些受体来设计和识别更好的药物。