Understanding how BH3-only proteins initiate apoptosis in response to chemotherapy

了解 BH3-only 蛋白如何启动化疗响应细胞凋亡

• 批准号: nhmrc : 1078924
• 负责人: A/Pr Grant Dewson
• 金额: $ 32.08万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-bh3-only-response-chemotherapy/518616
• 关键词: Understanding; how; BH3; only; proteins

Failure to initiate cell death is a hallmark in the development of the majority of cancers and killing all tumour cells is essential for effective cancer treatment. A group of proteins termed the BH3-only proteins normally sense cell stress to trigger cell death. Their dysregulation contributes to cancer and failure to respond to chemotherapy. Understanding how these proteins function to induce cell death will allow the design of drugs that mimic this activity for improved cancer therapy.

未能启动细胞死亡是大多数癌症发展的标志，杀死所有肿瘤细胞对于有效的癌症治疗至关重要。一组被称为BH 3-only蛋白质的蛋白质通常感知细胞应激以触发细胞死亡。它们的失调导致癌症和对化疗的反应失败。了解这些蛋白质如何诱导细胞死亡将允许设计模拟这种活性的药物，以改善癌症治疗。