Understanding causes of the rising incidence of thyroid cancer – What can mutations in the BRAF oncogene tell us about causes and diagnostic pathways for thyroid cancer?

了解甲状腺癌发病率上升的原因 — BRAF 癌基因的突变可以告诉我们有关甲状腺癌的原因和诊断途径的哪些信息？

• 批准号: nhmrc : 1047733
• 负责人: A/Pr Philippa Youl
• 金额: $ 40.69万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-causes-rising-thyroid-cancer/111963
• 关键词: Understanding; causes; rising; incidence; thyroid

The occurrence of thyroid cancer has increased rapidly over the last 25 years but the cause is unknown. The increase may reflect ‘over-diagnosis’ of less harmful cancers or greater exposure to causes of this cancer. Evidence suggests that a gene mutation (BRAF) in thyroid cancers is important in understanding the drivers of the increase. This study will examine the increase in thyroid cancer by investigating causes and diagnostic pathways considering the presence or absence of BRAF mutations.

甲状腺癌的发病率在过去25年中迅速增加，但原因尚不清楚。这一增长可能反映了对危害较小的癌症的“过度诊断”，或更多地暴露于这种癌症的病因。有证据表明，甲状腺癌中的基因突变（BRAF）对于理解这种增加的驱动因素很重要。本研究将通过研究BRAF突变存在与否的原因和诊断途径来检查甲状腺癌的增加。