Understanding the importance of Panton-Valentine leukocidin production in Australian isolates of Staphylococcus aureus.

了解澳大利亚金黄色葡萄球菌分离株中产生潘顿-瓦伦丁杀白细胞素的重要性。

• 批准号: nhmrc : 519402
• 负责人: Dr Kyra Chua
• 金额: $ 7.92万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-importance-panton-staphylococcus-aureus/115711
• 关键词: Understanding; importance; Panton; Valentine; leukocidin

New strains of the superbug methicillin-resistant Staphylococcus aureus (MRSA) have emerged in the community, causing severe, sometimes fatal infections in otherwise healthy people. These strains, called community-acquired MRSA produce a toxin (Panton-Valentine leukocidin). This project will provide important information about how this toxin promotes disease, and how the immune system responds to the toxin, providing the basis for the development of immunotherapies against this new superbug.

超级细菌耐甲氧西林金黄色葡萄球菌（MRSA）的新菌株已经在社区中出现，在健康人群中造成严重的，有时是致命的感染。这些被称为社区获得性MRSA的菌株会产生一种毒素（潘通-瓦伦丁杀白细胞素）。该项目将提供有关这种毒素如何促进疾病以及免疫系统如何对毒素作出反应的重要信息，为开发针对这种新型超级细菌的免疫疗法提供基础。