Understanding the mechanism of action for intravenous immunoglobulin (IVIG) therapy in spinal cord injury

了解静脉注射免疫球蛋白 (IVIG) 治疗脊髓损伤的作用机制

• 批准号: nhmrc : GNT1163835
• 金额: $ 60.54万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-mechanism-action-cord-injury/1379321
• 关键词: Understanding; mechanism; action; intravenous; immunoglobulin

Traumatic spinal cord injury is an important and costly cause of disability in Australia. The body's immune system plays a key role in the recovery from such injuries, but treatments to effectively target post-traumatic inflammation are lacking. This grant will test a promising new therapy, intravenous immunoglobulin (IVIG), and in particular uncover what cells and molecules are targeted by it so that we can better treat individuals affected by these devastating injuries.

在澳大利亚，创伤性脊髓损伤是造成残疾的一个重要且代价高昂的原因。身体的免疫系统在此类损伤的恢复中发挥着关键作用，但缺乏有效针对创伤后炎症的治疗方法。这笔赠款将测试一种有前途的新疗法——静脉注射免疫球蛋白（IVIG），特别是揭示它所针对的细胞和分子，以便我们能够更好地治疗受到这些毁灭性损伤影响的个体。