Understanding the mechanisms of PTEN transfer into glial cells using exosomes

了解使用外泌体将 PTEN 转移到神经胶质细胞中的机制

• 批准号: nhmrc : GNT1082159
• 负责人: Dr Andrew Morokoff
• 金额: $ 54.95万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-mechanisms-pten-using-exosomes/1345442
• 关键词: Understanding; mechanisms; PTEN; transfer; into

This application will develop a new way of treating brain cancer which currently affects 1500 adults in Australia per year with no lasting cures. The average patient with a malignant brain tumour do not survive for more than 12 months. We have discovered a method of restoring a cancer suppressor substance that is lost from brain tumours. If successful, this treatment has the potential to limit or reverse the progression of brain tumours.

这项应用将开发一种治疗脑癌的新方法，目前澳大利亚每年有1500名成年人受到脑癌的影响，没有持久的治愈方法。患有恶性脑瘤的病人平均活不过12个月。我们发现了一种方法，可以恢复从脑肿瘤中丢失的癌症抑制物质。如果成功，这种治疗有可能限制或逆转脑肿瘤的进展。