Molecular mechanisms of tumour-associated seizures

肿瘤相关癫痫发作的分子机制

• 批准号: nhmrc : 628301
• 负责人: Dr Andrew Morokoff
• 金额: $ 28.44万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-tumour-associated-seizures/101245
• 关键词: Molecular; mechanisms; tumour; associated; seizures

Seizures commonly develop in patients with brain tumours. Despite tumour resection, patients continue to experience seizures. Furthermore, patients can often be resistant to treatment with anti-epilepsy medications adding further burden to patient suffering, decreasing quality of life and overall survival. The cause is unknown and we propose identifiable causes are involved. This will provide effective targets for the development of medications for the treatment of these seizures.

癫痫发作通常发生在脑肿瘤患者身上。尽管肿瘤切除，患者继续经历癫痫发作。此外，患者通常会对抗癫痫药物治疗产生耐药性，从而进一步加重患者的痛苦，降低生活质量和总体生存率。原因不明，我们建议涉及可识别的原因。这将为开发治疗这些癫痫发作的药物提供有效的靶点。