Understanding the opposing roles of SWI-SNF in the control of gene programs for pathological cardiac hypertrophy

了解 SWI-SNF 在控制病理性心脏肥大基因程序中的相反作用

• 批准号: nhmrc : 526635
• 负责人: A/Pr Xiao-Jun Du
• 金额: $ 31.76万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-opposing-roles-cardiac-hypertrophy/77930
• 关键词: Understanding; opposing; roles; SWI; SNF

Following the success in decoding human genome, i.e. DNA sequence, a major task is to understand how the activity of genes with consequent changes in respective proteins. As proteins are an important component for cell structure and function, such changes in quantity and quality of proteins will play a pivotal role to affect disease development and progression.

随着人类基因组（即DNA序列）的成功解码，一项主要任务是了解基因的活性如何导致相应蛋白质的变化。由于蛋白质是细胞结构和功能的重要组成部分，因此蛋白质数量和质量的变化将对疾病的发生和发展起关键作用。