Understanding the multistep pathogenesis of T-cell leukaemia

了解 T 细胞白血病的多步发病机制

• 批准号: nhmrc : GNT1104145
• 负责人: A/Pr Matthew McCormack
• 金额: $ 70.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-multistep-pathogenesis-cell-leukaemia/1346332
• 关键词: Understanding; multistep; pathogenesis; cell; leukaemia

Lmo2 is a transcription factor whose overexpression is a common cause of T-cell leukaemia. This project seeks to identify downstream targets of Lmo2 that cause T-cell leukemia. In addition, the origins and effects of secondary mutations that collaborate with Lmo2 in causing T-cell leukaemia will be determined. This will improve our understanding of how T-cell leukaemia develops and provide new molecular targets for therapy.

Lmo2是一种转录因子，其过度表达是t细胞白血病的常见原因。该项目旨在鉴定导致t细胞白血病的Lmo2下游靶点。此外，与Lmo2协同引起t细胞白血病的继发性突变的起源和影响将被确定。这将提高我们对t细胞白血病如何发展的理解，并为治疗提供新的分子靶点。