Understanding new drug paradigms at M1 muscarinic receptors.

M1毒蕈碱受体是一种在记忆中起重要作用的脑蛋白，与阿尔茨海默氏症和精神分裂症有关。然而，这种蛋白质在目前的药物中仍然缺乏针对性。目前的提案将研究一类新的更具选择性的M1受体药物的作用机制。我们的研究将产生与制药行业和学术药物发现直接相关的宝贵信息。

The M1 muscarinic receptor is a brain protein that plays vital roles in memory, and has been implicated in Alzheimer�s and schizophrenia. However, this protein remains poorly targeted by current medications. The current proposal will investigate the mechanisms of action of a new class of more selective M1 receptor drugs. Our studies will generate valuable information that is directly relevant to the pharmaceutical industry and academic drug discovery.