The Importance of Receptor Trafficking for Signalling of Pain and Inflammation

炎症和疼痛是生存所必需的正常过程：炎症对抗感染，疼痛可以避免危险。这些过程通常受到严格控制，并且是短暂的。在疾病期间，它们变得失调和慢性。通过了解炎症和疼痛的正常过程，并通过确定失调如何导致疾病，我们的目标是开发新的治疗方法，这些疾病是人类痛苦的主要原因。

Inflammation and pain are normal processes that are essential for survival: inflammation fights infections and pain allows avoidance of danger. These processes are normally tightly controlled and are transient. During disease, they become dysregulated and chronic. By understanding the normal processes of inflammation and pain, and by determining how dysregulation causes disease, we aim to develop new treatments for diseases that are a major cause of human suffering.