Understanding the role of O-linked glycosylation in Burkholderia cenocepica for host survival using proteomic approaches

使用蛋白质组学方法了解新诺伯克霍尔德杆菌中 O-连接糖基化对宿主生存的作用

• 批准号: nhmrc : GNT1100164
• 负责人: Dr Nichollas Scott
• 金额: $ 22.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-o-proteomic-approaches/1346104
• 关键词: Understanding; role; linked; glycosylation; Burkholderia

The bacteria Burkholderia cenocepecia (Bc) is a common infection of Cystic Fibrosis suffers in Australia. ~20% CF patients infected with Bc will die due to lung failure. Due to this high death rate there is an urgent need to understand how Bc survives and causes disease in the host. This grant aims to understand how the attachment of sugars, a process known as glycosylation, affects the ability of Bc to survive in mammalian cells.

细菌伯克霍尔德氏菌cenoceptide（Bc）是一种常见的感染囊性纤维化在澳大利亚遭受。约20%的CF患者感染Bc后会因肺功能衰竭而死亡。由于这种高死亡率，迫切需要了解Bc如何在宿主中存活并引起疾病。这项资助旨在了解糖的附着，一个被称为糖基化的过程，如何影响Bc在哺乳动物细胞中生存的能力。