Understanding the role of sugar metabolism in liver tumour growth

了解糖代谢在肝肿瘤生长中的作用

• 批准号: nhmrc : GNT1108211
• 负责人: A/Pr Kyle Hoehn
• 金额: $ 63.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-sugar-tumour-growth/1346633
• 关键词: Understanding; role; sugar; metabolism; liver

Primary liver cancer is a deadly disease with limited chemotherapeutic options. The investigators of this proposal have recently determined that sugar intake (but not fat or complex carbohydrate) is a dominant driver of liver tumour growth in mice. The current proposal will investigate the specific contributions of glucose versus fructose in tumour burden, and determine whether blocking the conversion of sugars to fat in the liver represents a therapeutic strategy to block tumour growth in mice.

原发性肝癌是一种致命的疾病，化疗选择有限。该提案的研究人员最近确定，糖的摄入（而不是脂肪或复合碳水化合物）是小鼠肝脏肿瘤生长的主要驱动因素。目前的提案将研究葡萄糖与果糖在肿瘤负荷中的具体贡献，并确定阻断肝脏中糖转化为脂肪是否代表阻断小鼠肿瘤生长的治疗策略。