Understanding the role of Th22 cells in regulating respiratory immune responses in health and disease.

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T cells that produce the cytokine IL-22 (Th22 cells) are found in infectious and inflammatory lung disease. However, the role of Th22 cells in promoting or preventing disease remains largely unknown. We have discovered how to grow Th22 cells and have generated a unique strain of IL-22 reporter mice, which will allow us to identify their role in infectious and inflammatory diseases. Our investigations will provide new insights into therapeutic approaches for these diseases of the lung.