Understanding the role of tissue growth pathways in expansion of the lymphatic vasculature

了解组织生长途径在淋巴管系统扩张中的作用

• 批准号: nhmrc : GNT1165117
• 金额: $ 119.55万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-tissue-lymphatic-vasculature/1379387
• 关键词: Understanding; role; tissue; growth; pathways

Our lymphatics control tissue homeostasis and the pathogenesis of many diseases. Tumours induce lymphatic vessel formation and then invade via lymphatics and lymph nodes. We have identified a key tissue growth pathway involved in the expansion of lymphatic vessel beds. This project will investigate control of lymphatic vascular expansion, building on recent findings. The ultimate goal is to generate knowledge leading to approaches to manipulate lymphatics in disease settings in the future.

我们的组织学控制着组织的稳态和许多疾病的发病机制。肿瘤诱导淋巴管形成，然后通过淋巴管和淋巴结侵入。我们已经确定了一个关键的组织生长途径参与淋巴管床的扩张。这个项目将研究淋巴管扩张的控制，建立在最近的研究结果。最终目标是产生知识，从而导致未来在疾病环境中操纵生物学的方法。