Understanding the role of tissue growth pathways in expansion of the lymphatic vasculature

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Our lymphatics control tissue homeostasis and the pathogenesis of many diseases. Tumours induce lymphatic vessel formation and then invade via lymphatics and lymph nodes. We have identified a key tissue growth pathway involved in the expansion of lymphatic vessel beds. This project will investigate control of lymphatic vascular expansion, building on recent findings. The ultimate goal is to generate knowledge leading to approaches to manipulate lymphatics in disease settings in the future.