UNDERSTANDING THE BENEFITS AND LIMITATIONS OF METAPHASE II SPINDLE TRANSFER

线粒体DNA （mtDNA）疾病是从母亲的卵子传给她的孩子的。然而，受影响的mtDNA水平在她的卵子中有所不同。因此，携带者不知道新生儿是否患有这些疾病。线粒体捐赠使夫妇有可能拥有一个未受影响的孩子。我们将对线粒体捐赠进行最全面的研究，使用一种相关的方法来确定它是否能产生健康的胚胎和后代。

Mitochondrial DNA (mtDNA) diseases are transmitted from a mother's eggs to her children. However, the levels of affected mtDNA differ amongst her eggs. Consequently, a carrier would not know if the newborn child were to suffer from these diseases. Mitochondrial Donation offers couples the potential to have an unaffected child. We will undertake the most comprehensive study of mitochondrial donation using one of its associated approaches to determine if it produces healthy embryos and offspring.