Unravelling amygdala-hippocampus neural circuitry of anxiety: Role of adult-born neurons

揭示焦虑的杏仁核-海马神经回路：成年神经元的作用

• 批准号: nhmrc : GNT1165060
• 金额: $ 87.44万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-amygdala-hippocampus-born-neurons/1379381
• 关键词: Unravelling; amygdala; hippocampus; neural; circuitry

The addition of new neurons is a major regulator of brain function and plasticity, and is well understood in the hippocampus. We have discovered that new neurons are also generated in the amygdala, a region that processes emotional memories. Using animal models in which we can identify and manipulate adult-born neurons in these two regions, we will assess their contribution to the neural circuitry of the brain and their role in the pathogenesis and treatment of anxiety-related disorders.

新神经元的增加是大脑功能和可塑性的主要调节因素，并且在海马体中得到了很好的理解。我们发现，杏仁核也会产生新的神经元，杏仁核是处理情绪记忆的区域。利用动物模型，我们可以识别和操纵这两个区域的成年神经元，我们将评估它们对大脑神经回路的贡献，以及它们在焦虑相关疾病的发病机制和治疗中的作用。