Mechanisms of enhanced synaptic drive in basolateral amygdala following stress

应激后基底外侧杏仁核突触驱动增强的机制

基本信息

项目摘要

Project Summary Fear conditioning, where an initially neutral warning stimulus becomes associated with an innately aversive stimulus such as nociceptive electric shock, has proven to be an effective model for the study of learning and memory processes generally and how learned experiences contribute to anxiety disorders particularly. We reported that a single experience with a strong stressor leads to a long-term enhancement of fear learning, an effect we termed Stress-Enhanced Fear Learning (SEFL). Previously, we demonstrated the importance of the basolateral amygdala (BLA) in SEFL and that SEFL is accompanied by a long-term upregulation of the GluA1 subunit of the AMPA receptor, specifically in the BLA. AMPA receptors mediate normal excitatory neural transmission. This suggests that SEFL, and perhaps other negative consequences of stress, may be mediated by alterations in excitatory synaptic transmission. However, the precise mechanisms by which stress alters fear conditioning are not known. Such knowledge is important to understand how state variables impact learning and memory processes. Additionally, understanding how stress alters fear learning may point to translational targets for stress-related disorders. Therefore, we propose a series of studies using amygdala slice electrophysiology to address this gap in the literature and open the door to future studies determining the necessary and sufficient mechanisms for SEFL. Our preliminary data using whole-cell recordings indicates that there is enhanced excitatory drive in the basolateral amygdala following SEFL-inducing stress. In this exploratory application we propose to use BLA slice electrophysiology to achieve two aims. First to identify the specific inputs to the BLA that carries this enhanced excitatory drive. The second is to identify the molecular mechanisms responsible for this change in excitatory synaptic transmission focusing on the possibility that an abnormal form of neural plasticity underlies these maladaptive changes.
项目摘要 恐惧条件反射,最初中性的警告刺激与天生的厌恶相关联。 刺激,如伤害性电击,已被证明是一种有效的模型,用于研究学习和 一般的记忆过程以及学习经验如何导致焦虑症。我们 报告说,一个单一的经验,一个强大的压力源导致长期的增强恐惧学习, 压力增强恐惧学习(Stress-Enhanced Fear Learning,SEFL)在此之前,我们展示了 基底外侧杏仁核(BLA)在SEFL和SEFL是伴随着长期上调的GluA 1 AMPA受体的亚基,特别是在BLA中。AMPA受体介导正常兴奋性神经元 传输这表明自我外语,以及压力的其他负面后果,可能是由 兴奋性突触传递的改变。然而,压力改变的确切机制 恐惧条件反射是未知的。这些知识对于理解状态变量如何影响 学习和记忆过程。此外,了解压力如何改变恐惧学习可能会指出, 应激相关疾病的翻译靶点。因此,我们提出了一系列的研究,利用杏仁核 切片电生理学来解决文献中的这一空白,并为未来的研究打开大门, 有必要和充分的机制,以自我解放。我们使用全细胞记录的初步数据表明, 在SEFL诱导的应激之后,基底外侧杏仁核中存在增强的兴奋性驱动。在这 探索性应用我们建议使用BLA切片电生理学来实现两个目的。首先要确定 BLA的特定输入,携带这种增强的兴奋性驱动。第二是鉴定分子 负责兴奋性突触传递的这种变化的机制集中在一种可能性上, 神经可塑性的异常形式是这些适应不良变化的基础。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michael S Fanselow其他文献

Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress
急性创伤应激所致恐惧敏感化的诱导与表达
  • DOI:
    10.1038/npp.2015.224
  • 发表时间:
    2015-08-06
  • 期刊:
  • 影响因子:
    7.100
  • 作者:
    Jennifer N Perusini;Edward M Meyer;Virginia A Long;Vinuta Rau;Nathaniel Nocera;Jacob Avershal;James Maksymetz;Igor Spigelman;Michael S Fanselow
  • 通讯作者:
    Michael S Fanselow

Michael S Fanselow的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michael S Fanselow', 18)}}的其他基金

Acute vs Chronic Stress-Enhanced Fear Learning
急性与慢性压力增强的恐惧学习
  • 批准号:
    10368978
  • 财政年份:
    2018
  • 资助金额:
    $ 43.25万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    9977941
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    9484109
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    10219943
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
  • 批准号:
    9750570
  • 财政年份:
    2017
  • 资助金额:
    $ 43.25万
  • 项目类别:
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress Disorder
与创伤后应激障碍相关的恐惧回路中的 PACAP 信号传导
  • 批准号:
    8600320
  • 财政年份:
    2012
  • 资助金额:
    $ 43.25万
  • 项目类别:
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress Disorder
与创伤后应激障碍相关的恐惧回路中的 PACAP 信号传导
  • 批准号:
    8463349
  • 财政年份:
    2012
  • 资助金额:
    $ 43.25万
  • 项目类别:
Complete Fear Conditioning Suite for Rats and Mice
大鼠和小鼠的完整恐惧调节套件
  • 批准号:
    7794560
  • 财政年份:
    2010
  • 资助金额:
    $ 43.25万
  • 项目类别:
Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
神经免疫因素和共病恐惧、抑郁和饮酒
  • 批准号:
    7938672
  • 财政年份:
    2009
  • 资助金额:
    $ 43.25万
  • 项目类别:
Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
神经免疫因素和共病恐惧、抑郁和饮酒
  • 批准号:
    7810977
  • 财政年份:
    2009
  • 资助金额:
    $ 43.25万
  • 项目类别:

相似海外基金

Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
  • 批准号:
    10100360
  • 财政年份:
    2024
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
  • 批准号:
    24K04974
  • 财政年份:
    2024
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
  • 批准号:
    23K01686
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
  • 批准号:
    23K01692
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
  • 批准号:
    23K01695
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
  • 批准号:
    23K01713
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
  • 批准号:
    2312319
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
  • 批准号:
    23K01715
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
  • 批准号:
    10585388
  • 财政年份:
    2023
  • 资助金额:
    $ 43.25万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了