Mechanisms of enhanced synaptic drive in basolateral amygdala following stress
应激后基底外侧杏仁核突触驱动增强的机制
基本信息
- 批准号:10723781
- 负责人:
- 金额:$ 43.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-10 至 2025-09-09
- 项目状态:未结题
- 来源:
- 关键词:AMPA ReceptorsAccountingAddressAmygdaloid structureAnxiety DisordersAreaAuditoryAversive StimulusBehavioralBrain regionCalciumDataElectrophysiology (science)FrightFutureGoalsHippocampusHyperactivityKnowledgeLeadLearningLiteratureLong-Term PotentiationLoudnessMedialMediatingMental disordersModalityMolecularMusN-MethylaspartateNeuronal PlasticityNeuronsNociceptionNoisePainPathway interactionsPermeabilityPost-Traumatic Stress DisordersPrefrontal CortexReportingSensorySeriesShockSignal TransductionSliceSourceStimulusStressStressful EventStudy modelsSynapsesSynaptic TransmissionThalamic structureTimeUp-RegulationWhole-Cell Recordingsconditioned fearexperiencelearned behaviormemory processmidbrain central gray substanceoptogeneticsresponsestress reactivitystress related disorderstressortransmission process
项目摘要
Project Summary
Fear conditioning, where an initially neutral warning stimulus becomes associated with an innately aversive
stimulus such as nociceptive electric shock, has proven to be an effective model for the study of learning and
memory processes generally and how learned experiences contribute to anxiety disorders particularly. We
reported that a single experience with a strong stressor leads to a long-term enhancement of fear learning, an
effect we termed Stress-Enhanced Fear Learning (SEFL). Previously, we demonstrated the importance of the
basolateral amygdala (BLA) in SEFL and that SEFL is accompanied by a long-term upregulation of the GluA1
subunit of the AMPA receptor, specifically in the BLA. AMPA receptors mediate normal excitatory neural
transmission. This suggests that SEFL, and perhaps other negative consequences of stress, may be mediated
by alterations in excitatory synaptic transmission. However, the precise mechanisms by which stress alters
fear conditioning are not known. Such knowledge is important to understand how state variables impact
learning and memory processes. Additionally, understanding how stress alters fear learning may point to
translational targets for stress-related disorders. Therefore, we propose a series of studies using amygdala
slice electrophysiology to address this gap in the literature and open the door to future studies determining the
necessary and sufficient mechanisms for SEFL. Our preliminary data using whole-cell recordings indicates that
there is enhanced excitatory drive in the basolateral amygdala following SEFL-inducing stress. In this
exploratory application we propose to use BLA slice electrophysiology to achieve two aims. First to identify the
specific inputs to the BLA that carries this enhanced excitatory drive. The second is to identify the molecular
mechanisms responsible for this change in excitatory synaptic transmission focusing on the possibility that an
abnormal form of neural plasticity underlies these maladaptive changes.
项目摘要
恐惧条件作用,一开始中性的警告刺激变得与天生的厌恶有关
伤害性电击等刺激已被证明是学习和学习研究的有效模型。
一般的记忆过程,以及学习到的经验如何特别有助于焦虑症。我们
报道称,单一的经历与强大的压力源会导致恐惧学习的长期增强,以及
我们称之为压力增强恐惧学习(SEFL)的效果。在此之前,我们演示了
SEFL的杏仁基底外侧核(BLA)和SEFL伴随着GluA1的长期上调
AMPA受体的亚基,特别是在血乳酸中。AMPA受体介导正常兴奋性神经
变速箱。这表明,SEFL,也许还有其他压力的负面后果,可能是通过调节的
通过兴奋性突触传递的改变。然而,压力改变的确切机制
恐惧的条件反射是未知的。这些知识对于理解状态变量如何影响非常重要
学习和记忆过程。此外,了解压力如何改变对学习的恐惧可能会指向
应激相关障碍的翻译靶标。因此,我们提出了一系列关于杏仁核的研究。
切片电生理学来解决这一文献中的空白,并为未来确定
SEFL的必要和充分的机制。我们使用全细胞记录的初步数据表明
在SEFL诱导的应激后,杏仁基底外侧核的兴奋性驱动增强。在这
探索性应用我们提出利用BLA切片电生理学来实现两个目的。第一个确定
携带这种增强的兴奋性驱动的血乳酸的特定输入。二是鉴定分子
负责兴奋性突触传递这种变化的机制关注于一种可能性
神经可塑性的异常形式是这些不适应变化的基础。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael S Fanselow其他文献
Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress
急性创伤应激所致恐惧敏感化的诱导与表达
- DOI:
10.1038/npp.2015.224 - 发表时间:
2015-08-06 - 期刊:
- 影响因子:7.100
- 作者:
Jennifer N Perusini;Edward M Meyer;Virginia A Long;Vinuta Rau;Nathaniel Nocera;Jacob Avershal;James Maksymetz;Igor Spigelman;Michael S Fanselow - 通讯作者:
Michael S Fanselow
Michael S Fanselow的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael S Fanselow', 18)}}的其他基金
Acute vs Chronic Stress-Enhanced Fear Learning
急性与慢性压力增强的恐惧学习
- 批准号:
10368978 - 财政年份:2018
- 资助金额:
$ 43.25万 - 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
- 批准号:
9977941 - 财政年份:2017
- 资助金额:
$ 43.25万 - 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
- 批准号:
9484109 - 财政年份:2017
- 资助金额:
$ 43.25万 - 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
- 批准号:
10219943 - 财政年份:2017
- 资助金额:
$ 43.25万 - 项目类别:
Heterogeneity in Stress Effects on Fear Learning, Ethanol Consumption and Anxiety
压力对恐惧学习、乙醇消耗和焦虑影响的异质性
- 批准号:
9750570 - 财政年份:2017
- 资助金额:
$ 43.25万 - 项目类别:
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress Disorder
与创伤后应激障碍相关的恐惧回路中的 PACAP 信号传导
- 批准号:
8600320 - 财政年份:2012
- 资助金额:
$ 43.25万 - 项目类别:
PACAP Signaling in Fear Circuitries Relevant to Post-Traumatic Stress Disorder
与创伤后应激障碍相关的恐惧回路中的 PACAP 信号传导
- 批准号:
8463349 - 财政年份:2012
- 资助金额:
$ 43.25万 - 项目类别:
Complete Fear Conditioning Suite for Rats and Mice
大鼠和小鼠的完整恐惧调节套件
- 批准号:
7794560 - 财政年份:2010
- 资助金额:
$ 43.25万 - 项目类别:
Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
神经免疫因素和共病恐惧、抑郁和饮酒
- 批准号:
7938672 - 财政年份:2009
- 资助金额:
$ 43.25万 - 项目类别:
Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
神经免疫因素和共病恐惧、抑郁和饮酒
- 批准号:
7810977 - 财政年份:2009
- 资助金额:
$ 43.25万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 43.25万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别:
Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 43.25万 - 项目类别: