Unravelling how exosomes induce and propagate tau pathology
Unravelling how exosomes induce and propagate tau pathology
揭示外泌体如何诱导和传播 tau 病理学
批准号：
nhmrc : GNT1161133
负责人：
金额：
$82.75万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2019
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2019-01-01 至 --
中文摘要
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英文摘要
We have established that brains from mice with tau pathology produce tau seeds 'encapsulated' within extracellular vesicles known as exosomes. Furthermore, exosomes containing tau seeds can induce tau aggregation in recipient cells, and exosomes spread from neuron to neuron by hijacking endosomes. We aim to determine how exosomal tau seeds escape endosomes, and whether controlling the exosome production or traffic can halt or reduce tau pathology.
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