Unravelling NET confusion in Vasculitis

解开血管炎中 NET 的困惑

• 批准号: nhmrc : 2001325
• 金额: $ 104.41万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-net-confusion-vasculitis/1779765
• 关键词: Unravelling; NET; confusion; Vasculitis

Current therapy for AAV has major toxicities and 30% of Patients are dead or on dialysis within 3 years. This proposal aims to study a unique form of cell death termed Neutrophil extracellular traps (NETs) that initiates and perpetuates inflammation in this disease. We will use an animal model of the disease that mirrors human disease. We will inhibit crucial molecules in NET production to attenuate disease. This will provide proof of concept evidence to promote clinical trials in patients.

目前的AAV治疗具有严重的毒性，30%的患者在3年内死亡或接受透析。这项提案旨在研究一种独特的细胞死亡形式，称为神经细胞外陷阱（NETs），它在这种疾病中引发并维持炎症。我们将使用一种反映人类疾病的动物模型。我们将抑制NET生产中的关键分子以减轻疾病。这将为促进患者临床试验提供概念证据。