Unravelling how protein signalling networks integrate to control T cell fate

揭示蛋白质信号网络如何整合以控制 T 细胞命运

• 批准号: nhmrc : 1120748
• 金额: $ 27.82万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-protein-signalling-cell-fate/946618
• 关键词: Unravelling; how; protein; signalling; networks

Rational design of drug combinations to manipulate the immune response requires an understanding of how different signals work together to control cell behaviour. The PIM kinase proteins are known to regulate important properties of immune cells, including division and death and when dysregulated can lead to cancer. I will perform a comprehensive, unbiased investigation of how the PIM kinases interact with other protein signalling pathways to control the immune response in health and disease.

合理设计药物组合来操纵免疫反应需要了解不同信号如何协同工作来控制细胞行为。已知 PIM 激酶蛋白可调节免疫细胞的重要特性，包括分裂和死亡，当失调时可能导致癌症。我将对 PIM 激酶如何与其他蛋白质信号传导途径相互作用以控制健康和疾病中的免疫反应进行全面、公正的研究。