Use of Molecular Tumour markers to improve diagnostic performance of bronchoscopy in assessment of pulmonary nodules and early diagnosis of lung cancer

使用分子肿瘤标记物提高支气管镜在肺结节评估和肺癌早期诊断中的诊断性能

• 批准号: nhmrc : GNT1121880
• 负责人: A/Pr Daniel Steinfort
• 金额: $ 30.3万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/use-molecular-tumour-lung-cancer/1347232
• 关键词: Use; Molecular; Tumour; markers; improve

Pulmonary nodules may represent early lung cancer though difficulty in accurate diagnosis means many patients experience delayed diagnosis, or unnecessary surgical biopsy or repeat CT imaging (& consequent radiation exposure). I will identify molecular (DNA, protein) markers in bronchoscopic & blood specimens to accurately characterize malignant & benign nodules. These biomarkers will also be investigated for their value as a non-invasive screening test for lung cancer

肺结节可能代表早期肺癌，尽管准确诊断的困难意味着许多患者延迟诊断，或经历不必要的手术活检或重复CT成像(&随之而来的放射暴露)。我将在支气管镜和血液标本中识别分子(DNA，蛋白质)标志物，以准确地描述良恶性结节。这些生物标志物作为肺癌的非侵入性筛查试验的价值也将被调查。