Using Bioengineered 3D Models to Replicate the Tumour Microenvironment in Prostate Cancer

使用生物工程 3D 模型复制前列腺癌的肿瘤微环境

• 批准号: nhmrc : GNT1091734
• 负责人: Dr Nathalie Bock
• 金额: $ 30.94万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-bioengineered-3d-prostate-cancer/1345853
• 关键词: Using; Bioengineered; 3D; Models; Replicate

The research will address the poor prognosis of patients with advanced prostate cancer bone metastasis by establishing a novel 3D bioengineered bone model containing high amounts of fat cells, where cancer cells can relocate. This approach will help identifying the impact of fat cells on cancer cell function, and help determine whether fat cells are legitimate therapeutic targets, ultimately assisting clinicians to select better therapies for prostate cancer bone metastasis.

该研究将通过建立一种含有大量脂肪细胞的新型3D生物工程骨模型来解决晚期前列腺癌骨转移患者预后不良的问题，其中癌细胞可以重新定位。这种方法将有助于确定脂肪细胞对癌细胞功能的影响，并有助于确定脂肪细胞是否是合理的治疗靶点，最终帮助临床医生选择更好的前列腺癌骨转移治疗方法。