Using New Methods to Unravel the Genetics of Complex Disorders

使用新方法揭示复杂疾病的遗传学

• 批准号: nhmrc : GNT1053639
• 负责人: Dr Enda Byrne
• 金额: $ 21.1万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/using-new-methods-complex-disorders/1344549
• 关键词: Using; New; Methods; Unravel; Genetics

Advances in genomics have revolutionised research in the genetics of complex traits, but much of the genetic risk to disease remains unexplained. This project aims to utilise and integrate data from the latest genomic technologies such as next-generation sequencing, methylation arrays and gene expression arrays collected from large cohorts both in the United States and Australia to uncover the biological changes necessary for disease onset.

基因组学的进步彻底改变了复杂性状的遗传学研究，但许多疾病的遗传风险仍然无法解释。该项目旨在利用和整合来自最新基因组技术的数据，如从美国和澳大利亚的大型队列中收集的下一代测序，甲基化阵列和基因表达阵列，以揭示疾病发作所需的生物学变化。