Uterine-Targeted Delivery of Dual Action Therapy for Preventing Preterm Birth

孕激素是目前预防早产的主要疗法。不幸的是，许多女性对孕酮的松弛作用不敏感。我们发现了一种双重作用的药物，（1）维持子宫孕酮受体表达的状态与孕酮敏感性一致，（2）直接抑制子宫收缩。这种药物有可能增加对孕酮有反应的妇女的百分比，同时发挥“双重作用”作为保胎药。

Progesterone is currently a leading therapy for preventing preterm birth. Unfortunately, many women are insensitive to the relaxatory effects of progesterone. We discovered a dual-action agent that (1) maintains uterine progesterone receptor expression in a state that is consistent with progesterone sensitivity, and (2) directly inhibits uterine contractions. This agent has potential to increase the percentage of women that respond to progesterone, while exerting 'dual action' as a tocolytic.