Development of advanced photoacoustic, photothermal and photocarrier techniques and biosensors for biomedical, dental and optoelectonic diagnostics

开发用于生物医学、牙科和光电子诊断的先进光声、光热和光载流子技术以及生物传感器

• 批准号: 5622-2010
• 负责人: Mandelis, Andreas
• 金额: $ 4.37万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=449837
• 关键词: Development; advanced; photoacoustic; photothermal; photocarrier

The proposed research encompasses four distinct areas: 1a) semiconductor silicon contamination studies and 1b) Si solar-cell diagnostics using the technique of laser Photo-Carrier Radiometry (PCR), modulated electroluminescence (MEL) and dynamic lock-in PCR and MEL imaging (PCRI and MELI). 2) The development of a potentially breakthrough subsurface depth-selective instrumentation technique, the non-linear photo-acoustic radar/sonar (PAR) tomography for high-contrast, signal-to-noise ratio and resolution of deep subsurface imaging of cancerous lesions in soft tissues. When fully developed, this technology has the potential to deliver ultrasonic-quality image resolution, and to provide contrast between healthy and cancerous tissues rivaling that of magnetic resonance imaging (MRI) at a fraction of the cost. 3) The development of a combined photothermal radiometric (PTR) and modulated luminescence (LUM) lock-in imaging technique for real-time assessment of very early dental carious lesions. Two cameras will be used to capture multi-frequency images of LUM (near-IR camera) and of PTR (thermal-IR camera). The success of this dental imaging project may lead to a breakthrough safe dental clinical imaging technology to compete with ionizing X-radiographs in clinical settings. 4) The development of photoacoustic-luminescence radar/sonar (PAR-LUM) and a novel photothermal radiometric (PTR)-luminescence (LUM) radar, for very early bone osteoporosis diagnosis on Earth and in the weightless environment of space microgravity (disuse osteoporosis). The proposed research program is aimed at (1) boosting Canadian competitiveness in industrial electronics and alternative energy technologies through improved process quality control; (2) developing breakthrough techniques and biosensor instrumentation for the earliest possible detection of widespread diseases such as breast cancerous lesions, osteoporosis and dental demineralization caries; and (3) offering advanced training of HQP in multidisciplinary problems in key industrial and health sector areas in which Canada has an active presence and must continue competing internationally, or in new growth fields in which it should find opportunities to compete.

拟议的研究包括四个不同的领域：a)半导体硅污染研究和1b)硅太阳能电池诊断，使用激光光载流子辐射测量(PCR)、调制电致发光(MEL)和动态锁定PCR和MEL成像(PCRI和MELI)技术。2)发展了一种潜在的突破性的地下深度选择仪器技术--非线性光声雷达/声纳(PAR)断层成像，用于软组织癌病变的高对比度、信噪比和分辨率的深表面下成像。完全开发后，这项技术有可能提供超声波质量的图像分辨率，并以极低的成本提供可与磁共振成像(MRI)相媲美的健康和癌症组织之间的对比度。3)开发一种光热辐射(PTR)和调制发光(Lum)相结合的锁定成像技术，用于实时评估非常早期的龋损。将使用两个相机来捕捉LUM(近红外相机)和PTR(热红外相机)的多频率图像。这一牙科成像项目的成功可能会带来一项突破性的安全牙科临床成像技术，在临床环境中与电离X光片竞争。4)光声-发光雷达/声纳(PAR-LUM)和新型光热辐射(PTR)-发光(LUM)雷达的发展，用于在地球上和空间微重力失重环境(废弃性骨质疏松)中进行非常早期的骨质疏松症诊断。拟议的研究计划旨在(1)通过改进工艺质量控制提高加拿大在工业电子和替代能源技术方面的竞争力；(2)开发突破性技术和生物传感器仪器，以尽可能早地发现广泛传播的疾病，如乳腺癌病变、骨质疏松症和牙齿脱矿龋齿；以及(3)在加拿大有活跃业务并必须继续在国际上竞争的关键工业和卫生部门领域，或在它应该找到竞争机会的新增长领域，为HQP提供关于多学科问题的高级培训。