Nature and origin of carbohydrate mimicry

碳水化合物拟态的性质和起源

• 批准号: 38227-2009
• 负责人: Pinto, Mario
• 金额: $ 6.56万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=450749
• 关键词: Nature; origin; carbohydrate; mimicry

A program of research designed to exploit the concept of carbohydrate mimicry is proposed. The concept is of importance because of the need for tighter-binding drugs or more selective vaccine candidates. We have chosen several biologically important targets for the development of drug or vaccine candidates. These include an antibody of importance for the development of a vaccine against dysentry, a critical enzyme (UDP-galactopyranose mutase) necessary for survival of M. tuberculosis (and absent in humans), an enzyme (neuraminidase) critical for the propagation of influenza virus, and an antibody of importance for the development of a vaccine against Group B Streptococcus, the causative agent of meningitis in newborns.

提出了一项旨在利用碳水化合物模拟概念的研究计划。这个概念很重要，因为需要更紧密结合的药物或更具选择性的候选疫苗。我们已经选择了几个生物学上重要的靶点来开发药物或候选疫苗。这些抗体包括一种对研制痢疾疫苗具有重要意义的抗体，一种对结核分枝杆菌存活（在人类中不存在）至关重要的酶（udp -半乳糖酰脲酶），一种对流感病毒传播至关重要的酶（神经氨酸酶），以及一种对研制抗B群链球菌疫苗具有重要意义的抗体，B群链球菌是新生儿脑膜炎的病原体。