Nature and origin of carbohydrate mimicry

碳水化合物拟态的性质和起源

• 批准号: 38227-2009
• 负责人: Pinto, BrianMario
• 金额: $ 6.56万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=521494
• 关键词: Nature; origin; carbohydrate; mimicry

A program of research designed to exploit the concept of carbohydrate mimicry is proposed. The concept is of importance because of the need for tighter-binding drugs or more selective vaccine candidates. We have chosen several biologically important targets for the development of drug or vaccine candidates. These include an antibody of importance for the development of a vaccine against dysentry, a critical enzyme (UDP-galactopyranose mutase) necessary for survival of M. tuberculosis (and absent in humans), an enzyme (neuraminidase) critical for the propagation of influenza virus, and an antibody of importance for the development of a vaccine against Group B Streptococcus, the causative agent of meningitis in newborns.

提出了一个旨在利用碳水化合物拟态概念的研究计划。 这一概念很重要，因为需要更紧密结合的药物或更具选择性的候选疫苗。 我们选择了几个生物学上重要的靶点来开发候选药物或疫苗。 其中包括一种抗体，该抗体对抗结核疫苗的开发具有重要意义，是M.结核杆菌（并且在人类中不存在）、对于流感病毒的繁殖至关重要的酶（神经氨酸酶）和对于开发针对B族链球菌（新生儿脑膜炎的病原体）的疫苗重要的抗体。