Medicinal inorganic chemistry

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Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions, broad spectrum of ligand systems, panoply of techniques and collaborations, and various sources of financial support. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, EPR, electrochemistry, NMR, MS etc.) and biological studies are undertaken in the research programme. The success of this approach is the imminent entry of bis(ethylmaltolato)oxovanadium(IV) (also known as BEOV or AKP-020) into a phase IIa clinical trial in type 2 diabetes (www.akesis.com) - basic NSERC- and CIHR-funded research in coordination chemistry and pharmacology has yielded a clinically studied drug and potential oral therapy.