Thy-1 signaling in Th2, Th17, and T regulatory cell induction

Th2、Th17 和 T 调节细胞诱导中的 Thy-1 信号转导

• 批准号: 46295-2010
• 负责人: Hoskin, David
• 金额: $ 2.91万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=451054
• 关键词: Thy; signaling; Th2; Th17; regulatory

Specialized white blood cells called T helper cells and T regulatory cells are important components of the immune system. T helper cells produce an array of chemical messengers called cytokines that guide the development of the correct immune response needed to eliminate disease-causing microorganisms. T regulatory cells keep immune responses under tight control and help prevent the development of autoimmune diseases. However, before T helper cells and T regulatory cells can function properly, they must first be activated through a process that depends on physical interactions between the T cells and other specialized white blood cells called antigen-presenting cells. Dendritic cells are an important type of antigen-presenting cell. One of the structures found on mouse T cells that is involved in their activation is called Thy-1. Although human T cells do not have Thy-1 on their surface, they express similar molecules, one of which is called CD7. In a mouse model system, we will investigate the role that Thy-1 plays in the development of different populations of T helper cells that are specialized to protect against viruses, parasitic worms, and bacteria. We will also investigate the role of Thy-1 in T regulatory cell development. Mice are a useful model system in which to study mammalian immune responses, including those of human beings. In this case, the study of mouse Thy-1 will provide important clues to the function of similar molecules on human T cells. Our overall goal is to investigate the biochemical changes that take place in mouse T helper cells and T regulatory cells in response to Thy-1 stimulation. We will also determine whether signaling through molecules that are similar to Thy-1 have similar effects on T helper cell and T regulatory cell development. This research will add to our knowledge of T cell biology and may suggest new ways to enhance the activity of these important white blood cells.

被称为T辅助细胞和T调节细胞的特殊白细胞是免疫系统的重要组成部分。辅助性T细胞产生一系列被称为细胞因子的化学信使，这些细胞因子指导正确的免疫反应的发展，从而消除致病微生物。T调节细胞严格控制免疫反应，帮助预防自身免疫性疾病的发展。然而，在T辅助细胞和T调节细胞正常工作之前，它们必须首先通过一个过程被激活，这个过程依赖于T细胞和其他被称为抗原呈递细胞的特殊白细胞之间的物理相互作用。树突状细胞是一种重要的抗原呈递细胞。在小鼠T细胞上发现的一种参与激活的结构叫做Thy-1。尽管人类T细胞表面没有Thy-1，但它们表达类似的分子，其中一种叫做CD7。在小鼠模型系统中，我们将研究Thy-1在不同的T辅助细胞群的发育中所起的作用，这些T辅助细胞是专门用来抵御病毒、寄生虫和细菌的。我们还将研究Thy-1在T调节性细胞发育中的作用。小鼠是研究哺乳动物（包括人类）免疫反应的一个有用的模型系统。在这种情况下，对小鼠Thy-1的研究将为类似分子对人类T细胞的功能提供重要线索。我们的总体目标是研究小鼠T辅助细胞和T调节细胞在Thy-1刺激下发生的生化变化。我们还将确定通过与Thy-1相似的分子进行的信号传导是否对T辅助细胞和T调节细胞的发育有类似的影响。这项研究将增加我们对T细胞生物学的认识，并可能提出提高这些重要白细胞活性的新方法。