Impact of TRPV6 ligation on colonic epithelial cell-dendritic cell crosstalk during induction of an innate immune response

最近的研究结果证实了肠道上皮细胞之间沟通的重要性。 以及树突状细胞，这是一种白细胞，用于启动和调节宿主免疫反应。 可能参与这些重要相互作用的分子之一是钙通道，称为 TRPV6，具有信号特性，由结肠上皮细胞表达。山梨醇生物口服液 公司(SBI)已经开发出一系列与TRPV6结合并改变TRPV6活性的小蛋白，并正在 有兴趣确定这些蛋白与结肠上皮细胞的结合是否影响附近的能力 树突状细胞对细菌的“危险信号”作出反应。在这个合作研究项目中，我们将 确定TRPV6选择性多肽相互作用对树突状细胞产生不同种类 细菌DNA中存在的对CpG寡核苷酸的化学信使反应。此协作 为探索树突状细胞对“危险信号”的反应提供了一个独特的机会 肠上皮细胞TRPV6钙通道功能改变。

Recent findings have established the importance of communication between the epithelial cells that line the gut and dendritic cells, which are a type of white blood cell, for initiating and regulating host immune responses. One of the molecules that might be involved in these important interactions is a calcium channel, termed TRPV6, that has signaling properties and is expressed by epithelial cells in the colon. Soricimed Biopharma Incorporated (SBI) has developed a family of small proteins that bind to and alter the activity of TRPV6, and is interested to determine whether binding of these proteins to colonic epithelial cells affects the ability of nearby dendritic cells to response to a bacterial "danger signal". In this collaborative research project, we will determine the effect of TRPV6-selective peptide interactions on the ability of dendritic cells to produce various chemical messengers response to CpG oligodeoxynucleotide present in the DNA of bacteria. This collaboration represents a unique opportunity to explore the response of dendritic cells to "danger signals" in the context of altered TRPV6 calcium channel function of gut epithelial cells.