Viral factors involved in flavivirus replication and virus-host interactions

参与黄病毒复制和病毒与宿主相互作用的病毒因子

• 批准号: nhmrc : 455954
• 负责人: A/Pr Mario Lobigs
• 金额: $ 49.59万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-factors-involved-host-interactions/77392
• 关键词: Viral; factors; involved; flavivirus; replication

With our increased understanding of virus-host interactions it has become apparent that small, non-structural proteins and small RNAs of most viruses are vital for numerous, often multiple, functions in the viral life cycle. In the proposed project, we seek to gain a detailed understanding of the functions of small nonstructural protein NS2A and small abundant viral RNAs of medicaly important encephalitic flaviviruses, which have remained so far elusive and are at the cutting-edge in the research field. We anticipate that with a better understanding of the roles of these factors in flaviviral replication and pathogenesis, novel targets for antiviral therapies and-or molecular determinants for inclusion in candidate vaccines will be identified.

随着我们对病毒与宿主相互作用的了解不断加深，我们发现大多数病毒的小非结构蛋白和小 RNA 对于病毒生命周期中的众多（通常是多种）功能至关重要。在拟议的项目中，我们试图详细了解医学上重要的脑炎黄病毒的小非结构蛋白 NS2A 和小丰富病毒 RNA 的功能，这些功能迄今为止仍然难以捉摸，处于研究领域的前沿。我们预计，通过更好地了解这些因素在黄病毒复制和发病机制中的作用，将确定抗病毒治疗的新靶标和/或候选疫苗中包含的分子决定因素。