Molecular pathogenesis of emerging West Nile viruses

新出现的西尼罗河病毒的分子发病机制

• 批准号: nhmrc : 1045188
• 负责人: A/Pr Mario Lobigs
• 金额: $ 39.62万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-pathogenesis-emerging-nile-viruses/111724
• 关键词: Molecular; pathogenesis; emerging; West; Nile

West Nile virus (WNV) is a mosquito-borne virus that causes potentially fatal encephalitis in humans and horses. This project will investigate the recent emergence of pathogenic for horses WNV in Australia and the potential of this new isolate to cause severe disease in humans. We will define the viral and host factors determining the outcome of WNV infection. This project will provide knowledge on the factors involved in the emergence of virulent WNV strains from attenuated isolates.

西尼罗河病毒（WNV）是一种蚊子传播的病毒，可导致人类和马的潜在致命性脑炎。该项目将调查最近在澳大利亚出现的对马致病的西尼罗河病毒，以及这种新分离株在人类中引起严重疾病的可能性。我们将定义决定西尼罗河病毒感染结果的病毒和宿主因素。本项目将提供有关从减毒分离株中出现毒性WNV菌株的因素的知识。