Viral factors contributing to flavivirus-induced cell death and pathogenicity

导致黄病毒诱导的细胞死亡和致病性的病毒因素

• 批准号: nhmrc : 1009874
• 负责人: Dr Anneke Funk
• 金额: $ 40.87万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-factors-contributing-death-pathogenicity/109436
• 关键词: Viral; factors; contributing; flavivirus; induced

West Nile virus is a mosquito-transmitted pathogen that causes severe and fatal neurological disease in humans. There are currently no effective treatments or vaccines for this disease. In this project, we will investigate how West Nile virus and other viruses of the same group use a novel translational regulatory mechanism to modulate the host antiviral response and facilitate viral pathogenicity. This will provide valuable information for the development of effective treatments against this medically important group of viral pathogens.

西尼罗河病毒是一种蚊子传播的病原体，会导致人类严重和致命的神经系统疾病。目前还没有有效的治疗方法或疫苗来治疗这种疾病。在这个项目中，我们将研究西尼罗河病毒和其他同组病毒如何使用一种新的翻译调控机制来调节宿主的抗病毒反应，并促进病毒的致病。这将为开发针对这种医学上重要的病原体的有效治疗方法提供有价值的信息。