In vivo investigation of human PR3 transgenic mice: a novel animal model to understand the role of PR3 in chronic inflammation and autoimmune vasculitis
In vivo investigation of human PR3 transgenic mice: a novel animal model to understand the role of PR3 in chronic inflammation and autoimmune vasculitis
人 PR3 转基因小鼠的体内研究：一种了解 PR3 在慢性炎症和自身免疫性血管炎中作用的新型动物模型
批准号：
nhmrc : GNT1092602
负责人：
Dr Katherine Martin
金额：
$36.89万
依托单位国家：
澳大利亚
项目类别：
Early Career Fellowships
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 --
中文摘要
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英文摘要
Granulomatosis with polyangiitis (GPA) is a form of vasculitis and is associated with antibodies directed against proteinase 3 (PR3). PR3 is expressed in neutrophils, monocytes and macrophages and has a number of well-characterized pro-inflammatory functions. The aim of this project is to understand the role of PR3 in inflammation and autoimmune vasculitis in vivo. This will be achieved using a transgenic mouse model expressing human PR3.
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