In vivo investigation of human PR3 transgenic mice: a novel animal model to understand the role of PR3 in chronic inflammation and autoimmune vasculitis

人 PR3 转基因小鼠的体内研究：一种了解 PR3 在慢性炎症和自身免疫性血管炎中作用的新型动物模型

• 批准号: nhmrc : GNT1092602
• 负责人: Dr Katherine Martin
• 金额: $ 36.89万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vivo-investigation-human-autoimmune-vasculitis/1345886
• 关键词: vivo; investigation; human; PR3; transgenic

Granulomatosis with polyangiitis (GPA) is a form of vasculitis and is associated with antibodies directed against proteinase 3 (PR3). PR3 is expressed in neutrophils, monocytes and macrophages and has a number of well-characterized pro-inflammatory functions. The aim of this project is to understand the role of PR3 in inflammation and autoimmune vasculitis in vivo. This will be achieved using a transgenic mouse model expressing human PR3.

肉芽肿病伴多血管炎（GPA）是血管炎的一种形式，与针对蛋白酶3（PR3）的抗体有关。PR3在中性粒细胞、单核细胞和巨噬细胞中表达，并具有许多充分表征的促炎功能。本项目的目的是了解PR3在体内炎症和自身免疫性血管炎中的作用。这将使用表达人PR3的转基因小鼠模型来实现。