Development of tools for non-invasive human spinal cord research

开发非侵入性人类脊髓研究工具

• 批准号: 184139-2008
• 负责人: Stroman, Patrick
• 金额: $ 1.61万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=452537
• 关键词: Development; tools; non; invasive; human

Our knowledge of human spinal cord anatomy and function comes from invasive studies of anaesthetized animals, and from observations of the effects of injuries in humans, and from post-mortem studies. While these have yielded a wealth of information, there are still features that are poorly understood. The development of magnetic resonance imaging (MRI) has made it possible to observe human internal anatomy non-invasively, and functional MRI (fMRI) has enabled mapping of neuronal activity in response to a stimulus. Studies carried out in my lab with these methods have revealed previously unknown features of anatomy and function. For example, a link has been observed between attention to a sensation and neuronal activity in the spinal cord. We have also discovered that the motion of the spinal cord that occurs with each heart-beat decreases in amplitude lower in the cord, and the lumbar region is essentially motionless. This latter finding is the basis for the first part of this proposal.

我们对人类脊髓解剖和功能的了解来自对麻醉动物的侵入性研究，来自对人类损伤影响的观察，以及来自尸检研究。虽然这些已经产生了丰富的信息，但仍有一些特征鲜为人知。磁共振成像(MRI)的发展使得非侵入性地观察人体内部解剖成为可能，而功能磁共振成像(FMRI)则使得绘制神经元对刺激的反应活动成为可能。在我的实验室用这些方法进行的研究揭示了以前未知的解剖学和功能特征。例如，已经观察到对感觉的注意与脊髓中的神经元活动之间存在联系。我们还发现，每次心跳时发生的脊髓运动在脊髓较低处的幅度降低，而腰椎区域基本上是静止的。后一项发现是本提案第一部分的基础。